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Registered Nurse, Apheresis

City of Hope Chicago · Zion, IL · Full time

Posted Sep 21, 2026 · We last checked this listing on Oct 6, 2026

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Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a time a procedure did not go as planned. How did you respond?

What they are checking: Calm problem solving with technically complex equipment and patients.

What experience do you have with apheresis machines, dialysis or similar extracorporeal procedures?

What they are checking: Relevant technical background for learning this specialized procedure safely.

Tell me about a time you had to learn a complex new skill quickly.

What they are checking: Learning ability for a highly specialized role with a steep learning curve.

What would you do

Your patient's blood pressure drops during the procedure. What do you do?

What they are checking: Fast response to hemodynamic changes common during apheresis.

How do you work with the stem cell transplant team and lab to schedule and track collections?

What they are checking: Coordination skills that keep transplant timelines on track.

About the work

Walk me through how you prepare a stem cell donor for a peripheral blood stem cell collection.

What they are checking: Knowledge of donor screening, mobilization and preparation for a safe collection.

During apheresis your patient complains of tingling around the mouth and fingers. What is happening and what do you do?

What they are checking: Recognition of citrate toxicity and quick, correct management.

How do you manage the central line or access used for apheresis to prevent infection or clotting?

What they are checking: Vascular access care skills that protect patients undergoing repeated procedures.

How do you explain plasmapheresis to a patient who is nervous about the machine?

What they are checking: Clear patient teaching that eases fear and supports informed consent.

How do you make sure the collected product is labeled and handled correctly?

What they are checking: Chain of custody and labeling discipline that protect a transplant patient's cells.

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The full job description

As published by City of Hope Chicago.

Registered Nurse, Apheresis About City of Hope , City of Hope's mission is to make hope a reality for all touched by cancer and diabetes. Founded in 1913, City of Hope has grown into one of the largest and most advanced cancer research and treatment organizations in the U.S., and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center that is ranked top 5 in the nation for cancer care by U.S. News & World Report at its core, City of Hope’s uniquely integrated model spans cancer care, research and development, academics and training, and a broad philanthropy program that powers its work. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and cancer treatment centers and outpatient facilities in the Atlanta, Chicago and Phoenix areas. The Apheresis Nurse will provide technically complex procedures such as apheresis, plasmapheresis etc. for peripheral blood stem cell donors and patients, practicing the highest standard of care in the stem cell transplant program. In this role, the registered nurse will operate under the direction of a licensed practitioner to perform the procedure and provide nursing care. An individualized plan of care is provided including patient assessment, performing the procedure, and evaluating patient outcomes. The successful candidate: • Perform complex procedures such as apheresis, plasmapheresis etc. for peripheral blood stem cell donors and patients under the direction of a licensed practitioner in the stem cell transplant program. Recognize patient conditions requiring immediate actions, initiate appropriate life-supporting interventions while communicating appropriately with physicians • Perform patient assessment and evaluation, and technically complex apheresis procedures, maintaining accurate documentation of patient encounters. • Perform venipuncture and maintain peripheral access during the procedures. If central line, perform appropriate catheter care. • Coordinate with other members of the healthcare team to facilitate a smooth patient experience • Handles other related tasks such as quality control of equipment, as needed. Qualifications Your qualifications should include: • 1-2 years of apheresis or dialysis experience • Ultrasound guided IV insertion/Phlebotomy Experience • Bachelor of Science or equivalent in Nursing • Active RN license in the state of Illinois • BLS certification and must be maintained while in this position • Advanced Cardiac Life Support (ACLS) Certification City of Hope is an equal opportunity employer. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. Please note : City of Hope is committed to a safe and transparent hiring experience. Please be aware that scammers may attempt to impersonate our organization through fake job postings, emails or interviews. • Apply only through our official website or trusted partner platforms. • City of Hope will never request payment or fees at any stage of the hiring process. • We will not request sensitive personal or financial information prior to the acceptance of a formal offer. • All communications will come from official @coh.org email addresses. • Interviews are conducted only through approved, professional channels. • Be cautious of unsolicited communications, urgent requests or opportunities that seem inconsistent with standard hiring practices. • If you receive any suspicious communication, please report it to careers@coh.org .

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