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Registered Nurse, Infusion

City of Hope Chicago · Zion, IL · Full time

Posted Sep 24, 2026 · We last checked this listing on Oct 6, 2026

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Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a busy infusion day when several patients needed you at once. How did you decide what to do first?

What they are checking: Prioritization in a high-volume clinic where delays affect many patients and their treatment timing.

Tell me about a time you taught a patient something that helped them avoid a complication at home.

What they are checking: Patient teaching that sticks and reduces avoidable ER visits between treatments.

Do you hold chemo-biotherapy or OCN certification, and how have you kept your infusion skills current?

What they are checking: Formal oncology training and commitment to staying current in a fast-changing specialty.

What would you do

How do you guide the patient care partners working with you during an infusion shift?

What they are checking: Delegation and leadership, since the posting says the RN directly guides care partners.

A patient's labs come back with a low neutrophil count right before treatment. What do you do?

What they are checking: Whether they hold treatment and contact the provider rather than proceeding on schedule.

About the work

Walk me through how you verify a chemotherapy order before you hang it.

What they are checking: Rigorous independent double-check habits for high-risk drugs where an error can be fatal.

Your patient develops back pain, flushing and shortness of breath a few minutes into a monoclonal antibody infusion. What do you do?

What they are checking: Fast recognition of a hypersensitivity reaction and command of the steps to stop and treat it.

How do you manage a vesicant infusion through a port, and what would make you stop?

What they are checking: Knowledge of extravasation risk and the safety checks that protect patients from tissue damage.

You care for infusion patients of all ages. How does your approach change for an older adult versus a younger adult?

What they are checking: Age-appropriate assessment and teaching across the wide patient range the role serves.

How do you handle chemotherapy safely to protect yourself and others from exposure?

What they are checking: Knowledge of PPE and safe handling standards for hazardous drugs.

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The full job description

As published by City of Hope Chicago.

Registered Nurse, Infusion About City of Hope , City of Hope's mission is to make hope a reality for all touched by cancer and diabetes. Founded in 1913, City of Hope has grown into one of the largest and most advanced cancer research and treatment organizations in the U.S., and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center that is ranked top 5 in the nation for cancer care by U.S. News & World Report at its core, City of Hope’s uniquely integrated model spans cancer care, research and development, academics and training, and a broad philanthropy program that powers its work. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and cancer treatment centers and outpatient facilities in the Atlanta, Chicago and Phoenix areas. The successful candidate: • Assesses, plans, implements, evaluates and documents the care of medical and surgical patients requiring infusion therapy of all ages. Directly guides the care delivered by the patient care partners. • Demonstrates knowledge and use of chemotherapeutic agents and medications • Ability to assess and recognize normal/abnormal responses to treatments and institute appropriate interventions • Demonstrates skills to assess and intervene in life-threatening situations Qualifications Your qualifications should include: • 1 year of hospital or clinical setting as an RN • Graduate of NLNAC or CCNE school of Nursing • State of Illinois Registered Nurse License. • BLS certification upon hire and maintained in position. • Oncology Certification through ONCC when eligible or 6 oncology CE every year (18 oncology CE total every 3 years) for the Oncology Commission Cancer cycle. • ONS Fundamentals of Chemotherapy Immunotherapy Administration Course certified within 6-12 weeks of hire. City of Hope is an equal opportunity employer. City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location. Please note : City of Hope is committed to a safe and transparent hiring experience. Please be aware that scammers may attempt to impersonate our organization through fake job postings, emails or interviews. • Apply only through our official website or trusted partner platforms. • City of Hope will never request payment or fees at any stage of the hiring process. • We will not request sensitive personal or financial information prior to the acceptance of a formal offer. • All communications will come from official @coh.org email addresses. • Interviews are conducted only through approved, professional channels. • Be cautious of unsolicited communications, urgent requests or opportunities that seem inconsistent with standard hiring practices. • If you receive any suspicious communication, please report it to careers@coh.org .

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