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This position has closed. University of Chicago removed this listing from their careers page on Oct 6, 2026. The interview prep below is still useful, and there are similar open roles at the bottom of this page.

Staff Scientist

University of Chicago · Chicago, IL · $80,000–$100,000 a year · Full time

Posted Aug 19, 2026 · We last checked this listing on Oct 4, 2026

Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a mechanistic finding that did not replicate. What did you do?

What they are checking: Scientific honesty, which is the whole basis of a staff scientist's value.

What have you contributed to grants, and what exactly was your part?

What they are checking: An honest account of grant work, which is easy to inflate.

Tell me about mentoring someone in the lab.

What they are checking: Whether they develop people, which a senior scientific role requires.

What question would you most want to answer if you had the resources?

What they are checking: Whether they have a scientific direction of their own.

What would you do

How do you decide which of several promising directions a lab should pursue?

What they are checking: Judgment about a portfolio, which is what the scientific lead role is.

How do you work with surgeons whose time is scarce and unpredictable?

What they are checking: The practical reality of surgical research, which derails many projects.

How do you keep several projects moving when each has a different timeline?

What they are checking: Practical planning across a portfolio.

About the work

Walk me through a translational project you led from question to result.

What they are checking: Whether they have led a research programme rather than run assays within one.

What preclinical animal models have you designed and executed?

What they are checking: Real model experience, which the posting names and which is not transferable from cell work.

How do you work with human tissue specimens, from consent through analysis?

What they are checking: Whether they understand the regulatory and practical side, not just the bench.

Practice this interview out loud.

Offer builds a real interview for this exact role at University of Chicago from your resume and this job description, asks the questions one at a time, and tells you what landed. The first one is free.

Practice this out loud

The full job description

As published by University of Chicago.

Department BSD PED - Pediatric Genetics and Genomics About the Department ​​In the Department of Pediatrics, at the University of Chicago, we strive to provide the highest level of complex care for children from diagnosis and treatment to conducting research to find promising new therapies with a focus on teaching. ​We are committed to advancing the frontiers of knowledge, and the education and training of future clinical pediatricians, subspecialists, educators, clinical investigators and physician-scientists. The Department of Pediatrics is a dynamic, stimulating place to work, and because we are focused on growth and improved excellence, our staff have particularly challenging and rewarding roles.​ Job Summary ​​The University of Chicago’s Department of Pediatrics, Section of Genetics and Genomics in the Biological Sciences Division seeks a full-time Staff Scientist to support and advance an interdisciplinary research program focused on the genetic, genomic and molecular study of gene regulatory networks in developing organs, particularly cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we have identified an essential role for cilia-based Hedgehog signaling in cardiac progenitors, an essential aspect of mammalian cardiac development. Our studies have contributed to a paradigm shift in the understanding of cardiac morphogenesis, which is driven by events in cardiac progenitors rather than in the heart itself (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017).  We have recently identified a surprising and novel role for Hedgehog signaling in developmental timing control that will be the basis of future projects (Rowton et al. 2020). ​The incumbent’s primary activity will be academic research conducted in close collaboration with the Moskowitz Lab. The Research Staff Scientist will play a central role in analytic leadership, project coordination, and scientific ​development across multiple funded studies, including NIH-funded studies involving complex genetic, genomic and molecular study of gene regulatory networks in developing organs. ​This position is designed for an individual who brings strong quantitative expertise alongside the ability to coordinate scientific workflows, ensure analytic rigor and reproducibility, and contribute substantively to manuscripts, grant ​applications, and long-term program development. The role offers opportunities for intellectual leadership, cross-institutional collaboration, and sustained involvement in a growing research portfolio. Responsibilities • ​​Provide analytic leadership for clinical, administrative, and registry linked datasets, including development and implementation of analytic plans in collaboration with the Principal Investigator. • ​Ensure analytic rigor, reproducibility, and clear documentation of code, workflows, and outputs, support interpretation and visualization of results for manuscripts, presentations, and grant applications. • ​Coordinate scientific operations across multiple research projects and grants, managing timelines, milestones, and deliverables in alignment with funded aims. • ​Serve as a scientific liaison among team members and collaborators across institutions and disciplines; identify and troubleshoot analytic, scientific, or operational challenges. • ​Lead and oversee data governance and regulatory coordination, including DUAs, MOUs, data sharing agreements, and support for IRB submissions and compliance. • ​Contribute substantively to grant applications, progress reports, and manuscripts, including methods, analytic plans, preliminary data, and coordination of co-authors. • ​Support strategic development of the research program by identifying opportunities to enhance analytic capacity, data infrastructure, collaborations, and funding. • Serves as a resource for collecting data and performing analysis. Facilitates and promotes a research project by providing scientific or intellectual information. • Trains and mentors laboratory personnel. • Performs other related work as needed. Minimum Qualifications Education: Minimum requirements include a PhD in related field. Work Experience: Minimum requirements include knowledge and skills developed through 5-7 years of work experience in a related job discipline. Certifications: --- Preferred Qualifications Experience: • ​​Experience conducting and analyzing complex biomedical, genetic, genomic, molecular, or related scientific research. • ​Experience developing and implementing analytic approaches in collaboration with Principal Investigators and multidisciplinary research teams. • ​Experience contributing to scientific manuscripts, presentations, grant applications, or other scholarly research products. • ​Experience coordinating research activities across multiple projects, investigators, or collaborating institutions. Preferred Competencies • ​​Strong analytical, quantitative, and problem solving skills with the ability to interpret complex research data and scientific findings. • ​Strong knowledge of research methods, study design, and principles of scientific rigor and reproducibility. • ​Strong organizational and project coordination skills with the ability to manage multiple priorities, timelines, and deliverables. • ​Strong written and verbal communication skills, including the ability to communicate scientific information effectively and contribute to manuscripts, presentations, and grant applications. • ​Ability to work independently with sound judgment and initiative while collaborating effectively with Principal Investigators, multidisciplinary research teams, and external partners. • ​Strong attention to detail and working knowledge of research regulatory requirements, data governance, and applicable research policies and procedures.​ Working Conditions • ​​Laboratory environment. • ​Requires extended periods of computer work and data analysis. • ​May require occasional attendance at research meetings, presentations, or collaborative activities outside of regular work location. • ​May require flexibility to meet research, grant, publication, or project deadlines.​ Application Documents • Resume (required) • Cover Letter (​preferred​) The University of Chicago uses AI-assisted tools to streamline and augment some recruitment processes; however, AI is not used to make hiring decisions. When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application. Job Family Research Role Impact Individual Contributor Scheduled Weekly Hours 40 Drug Test Required No Health Screen Required Yes Motor Vehicle Record Inquiry Required No Pay Rate Type Salary ​ FLSA Status Exempt ​ Pay Range $80,000.00 - $100,000.00 The included pay rate or range represents the University’s good faith estimate of the possible compensation offer for this role at the time of posting. Benefits Eligible Yes The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook . Posting Statement The University of Chicago is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, or expression, national or ethnic origin, shared ancestry, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination. Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form. All offers of employment are contingent upon a background check that includes a review of conviction history. A conviction does not automatically preclude University employment. Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position. The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at: http://securityreport.uchicago.edu . Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.

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