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Staff Scientist

University of Chicago · Chicago, IL · $60,000–$70,000 a year · Full time

Posted Sep 28, 2026 · We last checked this listing on Oct 6, 2026

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Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a grant or manuscript you edited. How did you improve it?

What they are checking: Whether they can do the scientific editing this role emphasizes, making the science clearer and stronger.

This role is described as contributing original, creative intellectual work. What scientific ideas would you bring?

What they are checking: Whether they are a scientist with their own ideas, not only an administrator.

Tell me about a time you balanced research with administrative responsibilities.

What they are checking: Whether they truly want the mix of editing, planning and science this role offers.

What would you do

How would you help manage the daily operations of a group with more than 15 researchers?

What they are checking: Whether they can keep a busy lab organized while supporting the science.

A graduate student's project is stuck. How would you help without taking it over?

What they are checking: Whether they can support trainees while respecting their ownership of the work.

How do you handle a conflict between two lab members over shared equipment or credit?

What they are checking: Whether they can resolve tension fairly in a busy research group.

About the work

The Moellering lab works on chemical probes and in-cell chemoproteomics. Tell me about your hands-on experience with mass spectrometry-based proteomics.

What they are checking: Whether they bring the specific technical depth the lab's research depends on.

How would you approach annual progress reports for the lab's grants?

What they are checking: Whether they understand what funders expect and how to gather it from many researchers.

What's your experience keeping animal use and safety protocols current?

What they are checking: Whether they understand IACUC and safety compliance, which the lab cannot operate without.

How would you help with the lab's financial planning?

What they are checking: Whether they can track budgets and plan spending across grants.

Practice this interview out loud.

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The full job description

As published by University of Chicago.

Department PSD Chemistry: He Group About the Department One of the first departments founded at the University of Chicago was the Department of Chemistry. Since then, The University of Chicago has been the recipient of more than 73 Nobel Prize recipients, 15 of which came from the Department of Chemistry. Our current faculty have considerable strength in inorganic, organic, and physical chemistry, as well as in interdisciplinary research that delves into biology, physics, and materials science. Job Summary The principal contribution of a Staff Scientist is leading translational research projects under the mentorship of Dr. Chuan He in the Department of Chemistry. The He Lab seeks a highly experienced scientist with expertise in bioinformatics, next-generation sequencing technologies, and gene regulation. The candidate will lead research projects involving RNA modifications, RNA-RNA interactions, and small RNA-mediated gene regulation. The candidate must hold a Ph.D. degree in bioinformatics, or a related field and have over 4 years of postdoctoral research experience. Responsibilities • Perform routine and advanced molecular biology experiments, including nucleic acid extraction, purification, quantification, PCR/RT-PCR, and gel-based analysis. • Prepare and process RNA and DNA samples for next-generation sequencing (NGS) workflows, including library preparation and data analysis . • Design and perform related biochemical and molecular biology experiments to investigate and validate the function of small RNAs and their RNA-RNA interaction in gene expression regulation . • Support large-scale research projects aimed at studying biological mechanisms using bioinformatics approaches. • Operates in a highly collaborative mode with all members of the group and with others in the Institute and with off-campus collaborators. • Under general supervision of principal investigator, supervise and/or assist with the complex technical duties in a laboratory doing non-clinical research. • Compile documents and assists with interpreting presentations or reports stemming from scientific contributions in the laboratory. • Gives frequent internal and occasional external talks and tutorials on the thinking and work progress. • Leads the contributions to scientific writing and publications, including protocols and grants. • Mentor and supervise lab technician and undergraduate students within the group. • Performs experiments and collects and analyzes data. Participates in the promotion of a research project. • May present work at scientific meetings. • Performs other related work as needed. Minimum Qualifications Education: Minimum requirements include a PhD in related field. Work Experience: Minimum requirements include knowledge and skills developed through < 2 years of work experience in a related job discipline. Certifications: --- Preferred Qualifications Education: • PhD in Biology, Molecular Biology, Bioinformatics. Experience: • Previous Postdoctoral Scholar experience. Technical Knowledge or Skills: • Knowledge of basic computer proficiency including computer programs and standard laboratory equipment. • Knowledge of relevant scientific fields. • Knowledge of regulatory policies and procedures. Preferred Competencies • Demonstrated problem-solving, organization, analytical, and coordination skills including attention to detail. • Demonstrated excellent oral and written communication skills. • Demonstrated ability to read and comprehend scientific and technical literature, and methods to stay abreast of developments in the field. • Ability to work independently and as a part of a team and interact with a diverse workforce. • Ability to think creatively. • Demonstrated ability to articulate their scientific discoveries both in written publications and in talks. Application Documents • Resume (required) • Cover Letter (preferred) • Three Professional References (preferred) The University of Chicago uses AI-assisted tools to streamline and augment some recruitment processes; however, AI is not used to make hiring decisions. When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application. Job Family Research Role Impact Individual Contributor Scheduled Weekly Hours 37.5 Drug Test Required No Health Screen Required No Motor Vehicle Record Inquiry Required No Pay Rate Type Salary ​ FLSA Status Exempt ​ Pay Range $60,000.00 - $70,000.00 The included pay rate or range represents the University’s good faith estimate of the possible compensation offer for this role at the time of posting. Benefits Eligible Yes The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook . Posting Statement The University of Chicago is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, or expression, national or ethnic origin, shared ancestry, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination. Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form. All offers of employment are contingent upon a background check that includes a review of conviction history. A conviction does not automatically preclude University employment. Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position. The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at: http://securityreport.uchicago.edu . Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.

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