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Research Product Manager III

Tempus AI · Chicago, IL · $105,000–$145,000 a year · Full time

Posted Oct 1, 2026 · We last checked this listing on Oct 6, 2026

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Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a bioinformatics software product you managed. Who were the users and what did they need?

What they are checking: Whether they understand bioinformatics users well enough to lead the product, not just track tickets.

Tell me about a time you had to explain a technical tradeoff in cancer genomics to non-technical leaders.

What they are checking: Clear communication of complex science to people who make business decisions.

Tell me about a regulated device or diagnostic project that did not go as planned.

What they are checking: Honest reflection on regulated development and what they changed afterward.

What would you do

A translational research team wants a new feature fast, but it would need full revalidation of the clinical pipeline. What do you do?

What they are checking: Ability to balance research speed with the cost and risk of changing a validated system.

How do you work with algorithm developers to turn a research method into a production tool?

What they are checking: Whether they can bridge research code and robust, regulated software.

How do you prioritize a roadmap when research, clinical and commercial teams all have urgent requests?

What they are checking: A clear prioritization method tied to strategy rather than whoever asks loudest.

About the work

How do clinical regulatory requirements change the way you build software for a diagnostic test?

What they are checking: Experience with regulated software, including validation, traceability and design controls.

Walk me through how you would plan verification and validation for a new variant calling pipeline.

What they are checking: Technical depth in systems validation for genomic algorithms used in clinical settings.

How do you write requirements for a bioinformatics feature so engineers and scientists agree on what done means?

What they are checking: Skill in turning scientific needs into testable requirements.

What makes a genomic report useful to an oncologist?

What they are checking: Understanding of how genomic data is actually used in clinical decisions.

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The full job description

As published by Tempus AI.

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Sr. Technical Product Manager for Bioinformatics Software Passionate about making a difference in the world of cancer genomics? With the advent of genomic sequencing, we can finally decode and process our genetic makeup. We now have more data than ever before but providers don't have the infrastructure or expertise to make sense of this data. We’re on a mission to connect an entire ecosystem to redefine how genomic data is used in clinical settings. We are looking for a highly motivated and capable technical product manager with extensive experience and interest in translational cancer research, diagnostic test development, and systems validation and verification. This position requires experience with diagnostic products, clinical regulatory requirements for software systems,and algorithms development. Top candidates will also significant experience in regulated device development. This role will report to the head of Bioinformatics and support software product development functions. Responsibilities • Managing software development lifecycle processes. • Engaging with the quality and regulatory team and supporting quality processes. • Incident management: Promptly triage, coordinate, and manage the resolution of isues. • Stakeholder support: Provide dedicated and responsive support to all stakeholders using the bioinformatics software. • Feature request intake and prioritization: Collect, prioritize, and manage feature requests to guide software development. • Interfacing with Product Managers of downstream engineering teams during implementation. • Data contract management with downstream engineering teams. • Documentation: Maintain comprehensive and up-to-date documentation for all bioinformatics software. Required Experience: • Bachelors or M.S. in a scientific discipline • Significant experience in medical device development and regulatory submission • 2-4 years relevant experience in diagnostics product development • Familiarity with US FDA and EU IVDR regulatory frameworks. Ideal candidates will possess: • A track record of successful submissions to US and international regulatory agencies • Experience in cancer genetics, immunology, or molecular biology • Experience working with next-generation sequencing data • Self-driven and works well in interdisciplinary teams • Experience with communicating insights and presenting concepts to a diverse audience Pay Range: $105,000-$145,000 The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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