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This position has closed. Tempus AI removed this listing from their careers page on Oct 6, 2026. The interview prep below is still useful, and there are similar open roles at the bottom of this page.

Molecular Lab Supervisor

Tempus AI · Chicago, IL · Full time

Posted Sep 22, 2026 · We last checked this listing on Oct 4, 2026

Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a time you had to coach a technologist whose work quality was slipping.

What they are checking: Whether they address performance issues directly and fairly while supporting the person.

Tell me about a time you brought automation or robotics into a lab workflow. What went wrong along the way?

What they are checking: Whether they have practical experience validating and adopting automation, not just enthusiasm for it.

Tell me about a time you disagreed with a lab director or manager about a quality decision.

What they are checking: Whether they voice quality concerns upward clearly and still work within the chain of authority.

What would you do

How do you schedule training and competency assessments so they actually happen on time in a busy lab?

What they are checking: Whether they treat competency as a regulatory must and plan around production pressure.

Turnaround time is slipping and leadership wants more throughput, but your team is tired. What do you do?

What they are checking: Whether they balance speed, quality and staff wellbeing instead of just pushing harder.

A key instrument goes down in the middle of a run with patient samples on it. How do you handle the next few hours?

What they are checking: Whether they can protect samples, communicate delays and restore service under pressure.

How do you keep safety protocols from slipping when everyone is focused on turnaround?

What they are checking: Whether they model and enforce safety even when the lab is busy.

About the work

Walk me through a next-generation sequencing workflow from extraction to sequencing, and tell me where you'd focus quality review.

What they are checking: Whether they know the steps well enough to spot where quality problems usually start.

A QC metric drifts outside your established performance specifications. What remedial actions do you take, and when do you stop reporting results?

What they are checking: Whether they know when to halt testing and how to document corrective action under CLIA and CAP.

How do you prepare a molecular lab for CAP and New York State DOH inspections?

What they are checking: Whether they keep the lab inspection-ready all the time rather than scrambling before visits.

How do you investigate a possible contamination event in an NGS workflow?

What they are checking: Whether they can trace contamination systematically and decide which results are affected.

Practice this interview out loud.

Offer builds a real interview for this exact role at Tempus AI from your resume and this job description, asks the questions one at a time, and tells you what landed. The first one is free.

Practice this out loud

The full job description

As published by Tempus AI.

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. What You’ll Do: • Provide daily oversight of a cutting-edge molecular workflow to provide high-quality next-generation sequencing data with rapid turnaround times • Monitor laboratory processes to ensure that acceptable levels of analytic performance are maintained, to include review of quality control, instrument and equipment maintenance, and other quality assurance activities • Assure all remedial actions are taken whenever test systems deviate from the laboratory's established performance specifications • Perform quality review for samples within the sequencing workflow from extraction to sequencing. • Maintain CLIA/ CAP/ NYSDOH compliance • Schedule training and competency assessments for personnel • Mentor team of clinical molecular technologists and extraction technologists • Maintain safety within the laboratory and ensure all safety protocols are followed. • Utilize automation and robotics to standardize the discovery pipeline from sample acquisition to sequencing output • Schedule training and onboarding for new hires Qualifications: Must have: • One of the following educational requirements: • MD + 1 year clinical lab experience • PhD (physical, chemical, or biological science) + 1 years clinical lab experience • MS (physical, chemical, or biological science) + 2 years pertinent clinical lab experience • BS (physical, chemical, or biological science) + 4 years of pertinent clinical lab experience • Excellent communication skills • Ability to delegate tasks to others • Thrives in a fast-paced environment • Ability to work with others to plan and carry out scientific programs • Self-driven and works well in an interdisciplinary team with minimal direction • Strong desire to build products that will save lives and change the course of cancer • Impeccable attention to detail Highly Desirable: • Experience with next-generation sequencing • Experience supervising others • Work in a CLIA/CAP high-complexity laboratory • Experience with robotics and automated liquid handling systems • Knowledge of LIMS platforms and various computer systems Candidates must be able to work the assigned shift. Please note that shift assignment is based on technical level, experience, and current business needs. Current available shifts: Wed-Sat (2pm-12:30am) CHI: $60,000-$80,000 The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.