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Histotechnologist I

Tempus AI · Chicago, IL · Full time

Posted Sep 4, 2026 · We last checked this listing on Oct 6, 2026

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Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a time you caught a specimen identification error. What did you do?

What they are checking: Whether they treat sample identity as sacred, since a mix-up can send a patient the wrong result.

Tell me about a time you worked with a pathologist or coordinator to fix a slide quality issue.

What they are checking: Whether they take feedback and work as a team member rather than defending their slides.

What would you do

A pathologist sends back slides saying the staining is uneven. How do you work out the cause?

What they are checking: Methodical troubleshooting across processing, cutting and staining instead of just recutting.

You are behind on a large batch and a block keeps crumbling as you cut. What do you do?

What they are checking: Whether they protect precious tissue under time pressure rather than wasting it to stay fast.

The automated stainer throws an error mid-run. Walk me through what you do.

What they are checking: Calm equipment troubleshooting and knowing when to stop and escalate.

About the work

Walk me through how you section an FFPE block from the moment you pick it up to a finished H&E slide.

What they are checking: Real bench skill with the microtome, water bath and stainer, and the small steps that make a good section.

How do you decide on block orientation and knife angle to get a representative section?

What they are checking: Whether they understand that a poorly oriented section can hide the tissue the pathologist needs to see.

How do you cut a good frozen section on a cryostat, and what problems do you watch for?

What they are checking: Hands-on cryostat skill, including temperature, tissue type and chatter or folds.

How have you used a LIMS to track your work, and what happens if what you did is not recorded correctly?

What they are checking: Understanding that traceability in a LIMS is part of the job, not paperwork after it.

How do you keep up with equipment maintenance records, and why do they matter in a clinical lab?

What they are checking: Awareness that maintenance logs are needed for inspections and reliable patient results.

What safety practices do you follow with formalin, xylene and sharp blades?

What they are checking: Real habits around chemical and blade safety, which the posting stresses.

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The full job description

As published by Tempus AI.

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. What You’ll Do: • Preparation of both unstained and routine hematoxylin and eosin stained slides from formalin fixed paraffin embedded tissue blocks • Utilize microtome, water bath, automated stainer, automated coverslipper , tissue processors, and embedding centers • Determine appropriate block orientation and alignment, knife angles, and settings to obtain representative sections • Maintain specimen integrity through proper identification of samples, slides and folders • Cut frozen sections using a cryostat, stain samples for pathologists to review • Collaborate with in-house pathologists and pathology lab coordinators for slide quality review • Track work completed using a custom Laboratory Information Management System (LIMS) • Maintain laboratory equipment and record maintenance regularly • Approach work with safety and diligence and follow safety requirements of the laboratory • Perform routine workflows without direct guidance • Reliably produce quality finished products • Work collaboratively with other members of the Histology team to accomplish daily cutting and staining deadlines • Communicate effectively with pathologists, members of the histology team, and other associated teams as relates to workflow needs • Seek assistance from the lead, supervisor, and/or manager when problems or mistakes arise • Report issues with instrumentation, samples, or the lab itself in a timely manner Preferred Qualifications: • Certification not required • Associates preferred • Previous histology experience required • Laboratory • Knowledge of CAP regulations • Experience with pathology laboratory SOPs and protocols • Comfort with laboratory safety and training • Demonstrates problem solving skills in the laboratory • Good communication and organization skills Illinois Pay: $33.75/hour The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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