Senior Scientist I, Small Molecule and Peptide Bioanalysis
Posted Aug 7, 2026 · We last checked this listing on Sep 30, 2026
Likely interview questions for this role
Written from this job description, not a generic list. Each one notes what the interviewer is really checking.
About your past
You would independently evaluate and implement new analytical technologies. Tell me about a technique you brought into a laboratory.
What they are checking: Initiative and follow-through on technical change.
You would mentor junior scientists. What is hardest for someone new to bioanalysis to learn?
What they are checking: Teaching depth, visible through what they have seen people struggle with.
How do you stay current with the analytical literature while carrying a full study load?
What they are checking: A realistic habit, since the posting names staying current as a duty.
This asks for a doctorate with no minimum years, a master's with eight or more, or a bachelor's with ten or more, in the non-regulated bioanalysis group at North Chicago. What would you want to know about the portfolio and the instrumentation?
What they are checking: That they ask what they would actually be running.
What would you do
How do you decide a method is good enough for a non-regulated preclinical study?
What they are checking: Fit-for-purpose judgment, which differs from regulated bioanalysis.
You would support pipeline-enabling preclinical studies against timelines. How do you handle a study team that needs data faster than your method is ready?
What they are checking: Scientific integrity against program pressure.
About the work
This role supports quantitative bioanalysis of both small molecules and peptides. What makes peptide bioanalysis harder than small molecule work?
What they are checking: The specific technical challenge the posting centers on.
Walk me through developing a method for a peptide with poor recovery from plasma.
What they are checking: Extraction and method development depth, named as a core responsibility.
You would operate and maintain liquid chromatography and mass spectrometry instruments. Tell me about troubleshooting an instrument problem that was masquerading as an assay problem.
What they are checking: Diagnostic skill across the boundary between instrument and chemistry.
How do you tell a real result from a matrix effect or an artifact?
What they are checking: The central skepticism of bioanalysis.
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Practice this out loudThe full job description
As published by AbbVie.