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Senior Pharmacometrician

AbbVie · North Chicago, IL · Full time · Research

Posted Aug 24, 2026 · We last checked this listing on Oct 6, 2026

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Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a time your model disagreed with what the team expected. How did you handle it?

What they are checking: Holding a quantitative position against a clinical intuition.

This is a senior individual contributor role in clinical pharmacology at North Chicago, leading teams and analyses across programs. What do you want to know about which therapeutic areas you would support and how many programs at once?

What they are checking: Checking the real portfolio load before accepting.

What would you do

How do you decide when a simulation is informative and when it is just producing numbers?

What they are checking: Judgment about the limits of a model, which separates good pharmacometrics from output.

A trial's data quality is worse than expected. How does that change what you are willing to conclude?

What they are checking: Honesty about what the data can support.

How do you help senior management choose between action plans when the modeling only narrows the options rather than picking one?

What they are checking: Decision support under residual uncertainty, which this posting frames as a duty.

About the work

Walk me through a population pharmacokinetic analysis you led. What did it change about the development plan?

What they are checking: Modeling work judged by the decision it drove, not the model fit.

How do you explain an exposure-response relationship to a clinical team deciding on a dose?

What they are checking: Translation of modeling into a dosing decision, which is the job's point.

Walk me through writing a pharmacokinetic and pharmacodynamic analysis plan that a regulator will accept.

What they are checking: Regulatory document authorship, which this posting requires.

How do you bring mechanism of action and disease-specific context into an analysis so the interpretation is not purely statistical?

What they are checking: The multidisciplinary context this posting asks the pharmacometrician to provide.

Describe how you contributed to a common technical document submission. What was hardest about writing for that audience?

What they are checking: Experience with the submission format this posting names.

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The full job description

As published by AbbVie.

Conceive, execute and communicate multi-disciplinary modeling and simulations exercises to support development plans and strategies to achieve commercial goals and regulatory requirements for multiple functions. Generate new PK/PD modeling and simulation proposals and leads those efforts. Investigate, identify, develop, and optimize new methods and techniques in the field of PK/PD modeling and statistical data analysis. Consistently demonstrates excellent record of accomplishment of Pharmacometric and business objectives. Leads Pharmacometric and PK/PD modeling aspects of multiple projects. Responsible for critically evaluating technical and scientific aspects along with Clinical Pharmacology and Pharmacometrics management. Responsibilities • Execute strategy, lead teams and various data analyses and interpretation by providing necessary context (including explaining MoA and disease specifics, available relevant internal and external data, analysis plans, interpretation and discussion of model results in the context of research question). • Assist Clinical Pharmacology senior management in the selection of action plans that best meet business needs in drug development. • Author regulatory documents including PK/PD analysis plans, study reports, population PK reports, exposure-response analyses reports, common technical documents, label, white papers, and other similar documents. • Represent Pharmacometrics in Clinical Pharmacology and clinical project teams and presents in project team meetings and to Clinical Pharmacology Leadership. • Collaborate with the Clinical Pharmacology TA leads to develop a unified Clinical Pharmacology position. • Authors scientific publications and present at national and international conferences and interact with external stakeholders. • Participate in internal and external initiatives/working groups (e.g., process harmonization, IMI calls, ISoP groups). • PhD with typically 3+ years of experience in a relevant field, Master’s Degree or equivalent education and typically 9+ years of experience, Bachelor’s Degree or equivalent education and typically 13+ years of experience;(*relevant field includes experience with data science, mathematics, biostatistics, modeling and simulation, Pharmacometrics or systems pharmacology) • Excellent interpersonal skills • Ability to interact with functional representatives internally • Strategic thinking and enterprise view • Proven scientific track record and technical skills to perform the role • Key Leadership Competencies: o Delivers business results while also positioning AbbVie for long-term success o Persistent and resilient finds the way to move good ideas forward o Acts respectfully yet courageously o Connects unrelated concepts, generates original or unique ideas o Influences colleagues to achieve cross-functional alignment o Gives full accountability when delegating and accepts full accountability when delegated to by others Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​ • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​ • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​ • This job is eligible to participate in our long-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.​ AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

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