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This position has closed. AbbVie removed this listing from their careers page on Sep 25, 2026. The interview prep below is still useful, and there are similar open roles at the bottom of this page.

Principal Research Scientist II Central Core Function Operations Leader

AbbVie · North Chicago, IL · Full time · Research

Posted Aug 11, 2026 · We last checked this listing on Sep 22, 2026

Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

You would oversee vendor relationships and outsourcing. Tell me about holding an outsourced partner to a service expectation.

What they are checking: External partner oversight, named in both duties and qualifications.

You would lead a team across multiple functional areas. How do you manage people whose technical work you do not do yourself?

What they are checking: Leading specialists at arm's length from their bench work.

This asks for a doctorate with eight or more years, a master's with fourteen, or a bachelor's with sixteen, and is an operations leadership role rather than a bench science one. Why move to operations at this stage?

What they are checking: That they have chosen the operational track deliberately, not drifted into it.

What would you do

This role leads centralized operations supporting absorption, distribution, metabolism and excretion science, bioanalysis and translational sciences. How do you balance standardization against the flexibility scientists need?

What they are checking: The defining tension of a core operations role, stated in the leadership expectations.

A scientific team says a standardized process is slowing their science down. How do you respond?

What they are checking: Defending standardization without steamrolling the customers of the core.

You partner with scientific, technical, quality, automation, information technology and business stakeholders. How do you get clarity on who owns what when nobody has written it down?

What they are checking: Establishing roles across functions, named in the leadership expectations.

About the work

You would monitor operational performance through dashboards, metrics and business reviews. What metric actually tells you a laboratory core is healthy?

What they are checking: Whether they can pick a meaningful measure rather than list several.

You would strengthen laboratory support capabilities including automation and robotics. How do you decide what is worth automating in a scientific laboratory?

What they are checking: Automation judgment — payback, variability, scientist time.

The role asks you to anticipate operational risks and implement mitigation before they land. What operational risk in a laboratory core is most often missed?

What they are checking: Foresight grounded in real experience — sample integrity, instrument downtime, key person dependency.

How do you keep compliance expectations — quality systems, environment health and safety, instrument calibration — actually met day to day rather than at audit time?

What they are checking: Continuous compliance rather than periodic scramble.

Practice this interview out loud.

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The full job description

As published by AbbVie.

The Quantitative, Translational and ADME Science (QTAS) organization at AbbVie is seeking a highly motivated Principal Research Scientist II – Central Core Function Operations Leader to join the Non-regulated Bioanalysis team in North Chicago. This laboratory-based role provides strategic and operational leadership for a centralized organization supporting ADME, Bioanalysis, and Translational Sciences. The successful candidate will be responsible for developing and executing an efficient, compliant, and scalable operating model that advances scientific productivity, data integrity, and operational excellence. The Operations Leader partners with scientific, technical, quality, automation, IT, and business stakeholders to align priorities, standardize processes, improve workflows, and drive continuous improvement across laboratory operations. This position also provides leadership to a multidisciplinary team and serves as a key integrator across laboratory operations and enterprise support functions. Key Responsibilities • Lead centralized operational activities supporting ADME, Bioanalysis, and Translational Sciences core functions, ensuring alignment with business priorities, service expectations, quality standards, and timelines. • Partner with scientific and technical leaders to lead cross-functional initiatives, standardize processes, and strengthen laboratory support capabilities, including automation, IT-enabled workflows, sample logistics, operational metrics, data analytics, quality/compliance, EHS, calibration, and instrumentation coordination, including LC-MS systems and robotics. • Monitor operational performance through dashboards, metrics, and business reviews; identify trends, assess risk, and drive corrective actions while partnering with scientific and functional leaders to forecast demand, manage capacity, prioritize work, and ensure timely service delivery. • Oversee vendor relationships and outsourcing activities. • Lead and develop a team of professionals across multiple functional areas, fostering a culture of collaboration, accountability, inclusion, and operational excellence. • PhD with 8+ years, M.S. with 14+ years, or BS with 16+ years of experience in analytical chemistry, chemistry, life sciences, engineering, or a related field, with experience in scientific operations management and the pharmaceutical or biopharmaceutical industry. • Demonstrated experience leading operational workflows in a complex, cross-functional laboratory environment, with strong knowledge of laboratory systems, sample management, data flow, quality practices, and operational governance. • Experience leading and developing teams, with prior people leadership experience in a scientific or operational setting. • Experience with robotics, automation, laboratory IT systems, digital enablement, validation activities, and workflow improvement. • Proven ability to manage multiple priorities across stakeholders and deliver results in a fast-paced environment. • Strong analytical, organizational, problem-solving, communication, and influencing skills, with the ability to partner effectively across scientific and technical functions. • Experience leading outsourced operations, external partner oversight, dashboards, metrics frameworks, or operational reporting systems. • Working knowledge of compliance expectations, including quality systems, EHS practices, and instrument/calibration controls. Leadership Expectations • Serve as a visible and trusted operational leader of the centralized core organization. • Drive standardization and efficiency while balancing scientific flexibility and business needs. • Anticipate operational risks and proactively implement mitigation strategies. • Build strong partnerships with cross-functional leaders to ensure clarity of roles, responsibilities, and service expectations. • Model AbbVie values through integrity, accountability, collaboration, and a commitment to excellence. Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​ • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​ • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​ • This job is eligible to participate in our long-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.​ AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html