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Director – Process Engineering / Senior Principal Research Scientist

AbbVie · North Chicago, IL · Full time · Research

Posted Sep 22, 2026 · We last checked this listing on Oct 6, 2026

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Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a drug product you took from early development toward commercial readiness. What were the hardest decisions?

What they are checking: Whether they have led a product through development and made hard decisions along the way, showing real ownership rather than support.

Tell me about a time you led a team through a technical setback under timeline pressure.

What they are checking: Whether they can keep a team focused and steady through technical setbacks, which is common in drug product development.

How do you mentor engineers to become strong technical leaders?

What they are checking: Whether they deliberately develop engineers into technical leaders, which builds lasting strength in the function.

What would you do

A tablet shows content uniformity problems at scale. How do you investigate?

What they are checking: Whether they investigate scale-up problems systematically, finding the real cause rather than adjusting the process until it happens to pass.

At the director level, how would you set technical strategy for a process engineering function?

What they are checking: Whether they can set technical direction for a whole function, linking engineering priorities to the company's product pipeline.

About the work

Walk me through how you'd choose between direct compression, wet granulation and dry granulation for a new tablet.

What they are checking: Whether they choose a manufacturing process based on the drug's physical properties, rather than habit, since the wrong choice causes problems at scale.

How do you scale a granulation process from lab to commercial equipment?

What they are checking: Whether they understand the science of scaling granulation, since processes that work in the lab often behave differently on commercial equipment.

How do you use process modeling or PAT to reduce development risk?

What they are checking: Whether they use modeling and process analytics to reduce risk early, rather than relying only on trial and error.

How do you apply QbD and design space concepts in your development work?

What they are checking: Whether they build quality into development through QbD, which strengthens regulatory filings and makes later process changes easier to justify.

How do you work with formulation scientists and manufacturing sites during technology transfer?

What they are checking: Whether they can coordinate formulation and manufacturing teams through tech transfer, since gaps between them cause delays and failures.

How do you decide when a process is robust enough to move forward?

What they are checking: Whether they have clear criteria for process robustness, since moving forward too early leads to costly problems at commercial scale.

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The full job description

As published by AbbVie.

Are you a passionate engineer who thrives at the intersection of science, innovation, and impact? AbbVie's Research and Development Process Engineering team is on the front lines of transforming cutting-edge science into life-changing medicines — and we're looking for a Senior Principal Research Scientist or Director, Process Engineering to help us push the boundaries of what's possible in drug product development. This position is being posted at two potential levels — Principal Research Scientist I and Associate Director — and we welcome candidates who feel they are a strong fit for either level to apply. Join us at our North Chicago, IL hub and be part of something bigger. This isn't just a role — it's an opportunity to shape the future of drug manufacturing. Whether you join as a Sr Principal Research Scientist or step in at the Director level, you'll bring your proven project leadership in drug product development to drive synthetic molecule candidates from concept to commercial-ready processes, making real decisions that accelerate medicines to patients who need them most. At the Associate Director level, this role also carries broader accountability for setting technical strategy and may include direct people leadership responsibilities across the Process Engineering function. You'll be a master of drug product manufacturing platforms — direct compression, wet & dry granulation, hot melt extrusion, tableting, encapsulation, and film coating — and you'll apply your deep understanding of powder material properties to unlock new levels of manufacturability and product performance. When challenges arise, you're the person who steps up to troubleshoot complex process and material issues with creativity and rigor. And when it's time to go big, you'll translate bench-scale breakthroughs into pilot plant realities through expert scale-up execution. At AbbVie, we celebrate bold ideas, encourage experimentation, and give talented engineers and leaders the resources and autonomy to actually innovate. If you're ready to raise the bar, lead with influence, and leave your mark on some of the world's most important medicines — at either an individual-contributor or people/technical leadership level — we want to hear from you. Key responsibilities include: • Lead drug product manufacturing process early phase development for synthetic molecule development candidates within the AbbVie pipeline. • Collaborate with development CMC teams to ensure manufacturing processes are aligned with intended commercial manufacturing sites. • Advance scientific expertise within the function — mentoring peers and influencing senior leadership with your expert insights; at the Associate Director level, this includes providing technical leadership and, where applicable, direct oversight/management of team members. • Drive the development of technologies and scientific innovations that expand AbbVie's small molecule formulation capabilities. • Partner cross-functionally to build strategies that directly power AbbVie's drug discovery and development programs; at the Associate Director level, help shape department- and function-level strategy in partnership with senior leadership. • Champion compliance with AbbVie's safety, quality, and regulatory standards. • Bachelor’s Degree in Science related field with 18 years of related work; Master’s Degree Science or PharmD with 16 years of related work; PhD in Science or related field with 10 years of related work experience. • Proven ability to innovate with a history of new or improved product releases. • Interacts well with diverse groups within function and maintains strong working relationships with internal and external collaborators. Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​ • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​ • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​ • This job is eligible to participate in our long-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.​ AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

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