OfferDrill.

Jobs › Tempus AI

Anatomic Pathologist

Tempus AI · Chicago, IL · $240,000–$280,000 a year · Full time

Posted Jul 23, 2026 · We last checked this listing on Oct 6, 2026

Apply at Tempus AI

Likely interview questions for this role

Written from this job description, not a generic list. Each one notes what the interviewer is really checking.

About your past

Tell me about a research project where your pathology input changed the direction of the work.

What they are checking: Whether they collaborate actively with scientists rather than only signing out cases.

Tell me about a time you disagreed with a colleague's read. How did you resolve it?

What they are checking: Whether they handle diagnostic disagreement professionally and in the patient's interest.

What would you do

How would you help validate an AI algorithm or digital pathology workflow that's meant to assist your reads?

What they are checking: Whether they can contribute pathologist judgment to AI projects while staying critical about failure modes.

You have a stack of cases and a turnaround target, and one case needs much more time than the rest. How do you manage that?

What they are checking: Whether they balance throughput with taking the time a hard case truly needs.

How do you see the value of large curated cohorts, like the Tempus Molecular Ontology, for your day-to-day work?

What they are checking: Whether they connect individual case review to the larger data mission of the company.

About the work

When you review an H&E slide for NGS adequacy, what are you looking for and when do you reject a specimen?

What they are checking: Whether they understand tumor content, necrosis and tissue amount as they affect sequencing, not just diagnosis.

How do you approach PD-L1 scoring with clones other than 22C3, and what makes those cases tricky?

What they are checking: Whether they know clone-specific scoring rules and how mixing them up can change a treatment decision.

Walk me through a challenging mismatch repair IHC case, such as subclonal or patchy loss. How do you sign it out?

What they are checking: Whether they handle ambiguous MMR staining carefully and know when to recommend reflex molecular testing.

HER2-low has become important for antibody drug conjugates. How do you keep your scoring consistent at the low end?

What they are checking: Whether they appreciate how small scoring differences now change therapy eligibility.

How do you support a lab director in staying on top of proficiency testing and CAP checklist requirements?

What they are checking: Whether they understand the compliance work that sits behind clinical sign-out.

Practice this interview out loud.

Offer builds a real interview for this exact role at Tempus AI from your resume and this job description, asks the questions one at a time, and tells you what landed. The first one is free.

Practice this out loud

The full job description

As published by Tempus AI.

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Responsibilities: • Conduct preliminary pathology review (H&E review for specimen adequacy for NGS) for both research and clinical specimens • IHC sign out, with a focus on non-22c3 PD-L1 clones, challenging MMR cases and other predictive biomarkers for antibody drug conjugates (i.e. HER2) • Collaborate with multi-disciplinary team focused on answering key biological questions and keeping up with TMO (Tempus Molecular Ontology) cohorts • Participation in research projects as well as lab innovation projects, i.e. development of digital/remote pathology review, AI initiatives, new assay validation and other algorithms that necessitate Anatomic Pathology input, experience and collaboration • Specimen review will be performed on-site at our laboratory in downtown Chicago • Assist AP Lab Director with maintaining CLIA/CAP compliance and proficiency testing requirements • Assist with handling contractor questions, scheduling and other issues • Participate in pathology laboratory coordinator (PLC) education and training, as well as assisting with patient data abstraction as needed • Participate in and potentially lead PLC pre-pathology review and pathology review workflow improvements • Collaborate in creation and updating of standard operating procedure documentation and working instructions for PLCs and pathologists • Generally a M-F role, however the option to work a non-traditional schedule of Tuesdays through Saturdays can be discussed, if preferred Qualifications: ● MD/DO with a current Illinois medical license and board-certification in Anatomic Pathology ● Minimum of 1-2 years of anatomic pathology (i.e. general surgical pathology or sub-specialty and/or cytopathology) sign out experience preferred, although exceptional recent trainee graduates are also welcome to apply. ● Excellent managerial, organizational, reporting and communication skills ● Experience working in a regulated clinical laboratory environment (CLIA/CAP/NYSDOH/QSR) ● Experience ensuring compliance of a clinical laboratory to regulatory standards Chicago Pay Range: $240,000-$280,000 The expected salary range above is applicable if the role is performed from Illinois and may vary for other locations (California, Colorado, New York). Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position. We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Apply at Tempus AI